Solution

A pattern-based screening pipeline

Layer 1

Sequence pattern

Hidden Markov models (HMMs) sequence search against regulated genes and pathogens.

Sequence pattern figure

Layer 2

Structure pattern

Fast structure search against catalytic and interacting motifs from known toxic proteins.

Structure pattern figure

Layer 3

Surface pattern

Recognising and comparing patterns in protein surfaces including geometric and chemical features.

Surface pattern figure

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